Negative staining is a powerful preparative method for studying particulate specimens. In principle, the specimen is surrounded by heavy metal atoms that act as an electron barrier. Because the ...

In contrast to direct stains that bind to bacteria directly, a negative stain colors the background of a smear rather than the bacteria. These stains have negatively charged functional groups so they ...

Researchers performing cryo-EM experiments can acquire the training to make their own cryo-EM and negative-stain grids, and collect and process their own high-resolution data. We also offer sample ...