Nature4y
NF-κB activation promotes chronic inflammation and tumor progression in gastric cancer
Now, a recent report from Wu et al. confirms that Helicobacter pylori induced NF-κB activation is related to chronic inflammation and carcinogenesis in gastric cancer. To investigate the ...
Nature4y
Structure and signaling of Toll-like receptors
The final targets of TLRs are DNA-binding transcription factors (such as NF-kB and IRFs) that activate specific patterns of gene expression in the nucleus. The signaling system is conserved in the ...
Baylor College of Medicine1mon
Crosstalk Between Stress Granules and Innate Immunity
Recent work has shown us that G3BP nucleation of stress granules in the absence of virus infection activates PKR, resulting in phosphorylation of eIF2alpha and activation of NF-kB and JNK signal ...