Dysferlin is essential for plasma membrane repair, and mutations in this protein cause various muscle diseases. Here the authors report the structure of dysferlin, offering insights into its ...

The investigators studied the membrane-targeting sequence (MTS ... Shown are scans of representative gels and a quantification of the average amount of protein (± SD) contained in the different ...

Sören Brandenburg have identified a protein that plays a central role ... the cells to adapt to increased stress by forming new membrane structures. These findings could pave the way for new ...

Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York 10065, United States Tri-Institutional PhD Program in Chemical Biology, New York, New York 10065, ...

As a potent HSP90 C-terminal inhibitor, silybin has been shown to inhibit HSP90 without affecting certain client proteins, thus holding promise for reducing the wide ... the potential enhancement of ...

The latest version of Google DeepMind and Isomorphic Labs’ AlphaFold model can predict the structure and relationships not only of proteins, but “all of life’s molecules”, according to its ...

If you're keen to save on your setup, the best membrane keyboards can help you stay nimble on the battlefield without breaking the bank. These decks won't hold up to their premium mechanical ...

Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation).

Nov. 27, 2024 — Using 'DNA origami' scientists have built innovative nanostructures that pave the way for advanced robotics that can deliver targeted drugs -- plus they made a tiny map of ...

This work will be of high interest to a broad swathe of scientists studying native macromolecules present at low concentrations in cells. Cryo-EM single-particle analyses typically require target ...