This important study introduces rationally designed, genetically encoded tools for the selective and reversible ablation of excitatory and inhibitory synapses. The evidence is convincing, supported by ...

Aberrant synapse development can have pathological consequences for circuit function as demonstrated by the manifestation of devastating neurological impairments, including epilepsy and autism ...

However, a series of weak stimuli can combine, increasing the amount of neurotransmitter that is released. This results in enough neurotransmitter being diffused across the synaptic cleft to ...

Complementary, inhibitory synapses account for the long-lasting stability of excitatory synaptic modifications, providing the ...

A new study reveals how NREM sleep enhances cognitive performance by synchronizing neural activity and improving information ...

An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...

While excitatory neurons pass on the input ... These additional synapses increase the impact of inhibitory neurons and dampen ...