Recent predictions of enzyme–substrate interactions suggest a conserved binding pocket and enable the engineering of mutant lasso cyclases that broaden substrate tolerance.
Recent predictions of enzyme–substrate interactions suggest a conserved binding pocket and enable the engineering of mutant lasso cyclases that broaden substrate tolerance.
This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...
Nov. 26, 2024 — A team of researchers has developed an innovative imaging platform that promises to improve our understanding of cellular structures at the nanoscale. This platform, called ...
Support for this hypothesis is found in the observations that high glucose concentrations increase intraislet peroxide levels, that islets contain very low levels of antioxidant enzyme activities ...
Broadly, these enzymes fall into 5 categories based on substrate specificity ... and inhibited by binding to specific inhibitors known as tissue inhibitors of metalloproteinases (TIMPs).
Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...