The microscopes are equipped with direct electron detectors (Gatan K3 and Thermo Falcon 4i) to enable atomic resolution visualization of biological samples. A Selectris X energy filter facilitates ...

Cryoelectron microscopy is a method for imaging frozen-hydrated specimens at cryogenic temperatures by electron microscopy. Specimens remain in their native state without the need for dyes or ...

First presented at M&M Virtual 2020, this webinar demonstrates how cryo-electron microscopy (cryo-EM) has taken enormous strides. Structural analysis of viruses and proteins at the atomic level ...

Electron microscopy uses a beam of electrons to illuminate a sample and achieve much higher spatial resolution than light microscopy. Transmission electron microscopy generates an image of the ...

Pipeline for particle picking in cryo-electron microscopy images using convolutional neural networks trained from positive and unlabeled examples. Also featuring micrograph and tomogram denoising with ...

The cryogenic electron microscopy (cryo-EM) field exploded in popularity during the 2010s' "resolution revolution." The 2017 Nobel Prize in Chemistry awarded Jacques Dubochet, Joachim Frank, and ...

In this article, we will discuss the integration of cryo-electron microscopy into virology research and the unique challenges posed by working with hazardous virus species in biosafety laboratories.

This fundamental study demonstrates a novel method for imaging glutamate receptors in situ via cryo-ET. The use of cutting-edge methods is well-described and is compelling. This paper is broadly ...

CryoDRGN has proven a powerful deep learning method for heterogeneity analysis in single particle cryo-EM. In particular, the method models a continuous distribution over 3D structures by using a ...