Interestingly, we found that MMPP effectively inhibits a cyst-promoting gene program downstream of the cAMP-CREB pathway, a crucial signaling pathway implicated in ADPKD progression. Mechanistically, ...

It presents solid evidence that maternal obesity induces genomic methylation alterations in oocytes, which can be partly transmitted to F2 in females, and that melatonin is involved in regulating the ...

Exogenous melatonin treatment significantly reduces the hyper-methylation of HFD oocytes. The higher expression of DNMT3a and DNMT1 in HFD oocytes is also decreased by melatonin supplement, which may ...

NYU Grossman School of Medicine is a founding member of the Consortium of Accelerated Medical Pathway Programs (CAMPP). Formed in 2015 with eight medical schools and funded by the Josiah Macy Jr.

For we are labourers with God: ye are God's husbandry, ye are God's building (1 Corinthians 3:9). The Bible does not say we are labourers for God, but we are labourers (fellow-workers) with God. He ...

Sun et al develop a novel approach based on melanin-like nanoparticles to improve disease progression in animal models of PKD, and attribute its efficacy to a dual mechanism of inhibition of cAMP/CREB ...

本研究论文聚焦锂负载电纺丝纳米纤维支架增强大鼠坐骨神经轴突再生和功能恢复。越来越多的证据表明，经过工程改造的神经移植在周围神经损伤（PNIs）再生方面具有巨大潜力。虽然大多数研究仅关注移植物的形貌特征，但我们在应用纳米支架时考虑了生物 ...

Train employees with Microsoft 365 learning pathways, a digital, customizable learning solution that helps customers transform their organization. Microsoft 365 learning pathways provides: ...