In mouse models of prostate cancer, MTX-101 delivered twice a week reduced tumor growth, lung metastases, bone remodeling, and tissue loss induced by the presence of metastatic cancer cells in the ...

Zoledronic acid is a potent, new-generation bisphosphonate indicated for the treatment of documented bone metastasis in patients with solid tumors and bone lesions associated with multiple myeloma.

It is becoming increasingly clear that cancer cells play an active part in stimulating bone-marrow-derived cells (BMDCs) to create a microenvironment that is favourable for metastasis (the ...

We will specifically focus on micrometastases in bone, an organ most frequently affected by breast cancer metastasis. Toward this end, we have developed a set of unique techniques and experimental ...

Raman is also a member of the Johns Hopkins Kimmel Cancer Center. “We first had to determine whether DDX3 was expressed in ...

After determining that breast cancer bone metastasis cells had high levels of DDX3, the research team turned to mice to test if RK-33 had any effect on the DDX3 protein and function of the cancer ...

Metastasis remains the primary challenge to ... The new tumor is still colorectal cancer (not brain, liver, or bone cancer), yet the cells in the new tumor are also radically different from ...

What is Cancer Metastasis? Metastasis is the word used when cancer spreads to a part of the body other than where it started. The cancer cells that spread are the same type of cells as where the ...

Metastasis remains the primary challenge to ... The new tumor is still colorectal cancer (not brain, liver, or bone cancer), yet the cells in the new tumor are also radically different from ...

Metastatic breast cancer (MBC) is the most common cancer-related ... in the body -- including from the brain, liver, and bones -- and represented different clinically relevant subtypes.