The most severe injuries have been associated with widespread axonal and myelin degeneration (Gentili, Hudson, and Hunter, 1980a). Pathological alterations in the nerve were evident as early as 30 ...

[1] Although axons in the PNS harbor the potential of axonal regeneration, recovery of severe peripheral nerve injury is often unsatisfactory. This undesirable outcome is believed to be related to ...

Cellular stress signaling is critical for determining the fates of neurons in injury and disease. In some cases, such as peripheral nerve injury, stress signaling initiates a response that can result ...

This molecular shift improved nerve regeneration capacity, indicating that axon regrowth is regulated by an inhibitory ...

Consequently, nerve injuries in the legs and arms often ... Targeting vasohibins to promote axon regeneration, The Journal of ...

Myofibroblasts generate fibrotic scars after spinal cord injury (SCI). This is typically regarded as an impediment to nerve regeneration. Understanding the heterogeneous characteristics of ...

A team led by researchers at the University of Georgia screened compounds for the ability to treat familial dysautonomia (FD) ...

The study shows that contracting muscles release biochemical signals, or myokines, which significantly enhance neuron growth.