Arginine and ornithine are precursors of nitric oxide and polyamines, respectively. These metabolites intimately participate in permeability and adaptive responses of the gut. The liver possesses high ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized primarily by the formation of heterotopic ...

Results The GCPM ecosystem coordinates a unique immunosuppressive pattern distinct from that of primary GC, which is dominated by a stroma-myeloid niche composed of SPP1+tumour-associated macrophages ...

This limits the wide impact of this study but can be used as a starting point to examine sex- and age differences in the transcriptome due to alternative splicing. Complex diseases often exhibit ...

Purpose: To characterize in mice of both genders with HFpEF the cardiac pro-inflammatory and the protective resident repair Mo. Methods: 12-week-old male and female C57BL/6N mice received HFD (60% ...

The biotechs teamed up to develop a method to engineer immune cells called macrophages to target solid tumors. Weekly dosing of the therapy, dubbed CAR-M, shrank lung and liver tumors in mice ...

Unknown. Multiple in silico algorithms yielded conflicting results.

“We figured out later that macrophages were converting arginine into citrulline, nitrite, and nitrate,” he says. Despite those important findings, Marletta failed to obtain tenure at MIT. “MIT is a ...