At the end of the study, propellant loss in the Proventil HFA test MDIs increased threefold over that in the controls. The Ventolin HFA test MDIs also had an increased leak rate compared with ...

Purpose: The effects of extreme temperatures on drug delivery of two albuterol sulfate hydrofluoroalkane, metered-dose inhalers (MDIs) were evaluated.Methods. Three Proventil HFA and three ...