Introduction Women who inherit a pathogenic mutation in Breast Cancer Susceptibility Genes 1 or 2 (BRCA1 or BRCA2) are at substantially higher risk of developing breast and ovarian cancer than the ...

Protocol: Association between sedentary time, physical activity, biochemical markers in the blood (heart and muscles) and heart failure in adults with congenital heart disease: a study protocol of a ...

Objectives Examination of current temporal trends and clinical management patterns of eating disorders (ED) in primary care is lacking. We aimed to calculate annual incidence rates of EDs in primary ...

Introduction Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising ...

Background Virtual reality (VR) is a technology that produces a virtual manifestation of the real world. In recent years, VR has been increasingly used as a tool in medical education. The use of VR in ...

Objective To assess the clinical and haemodynamic effects of carvedilol for patients with cirrhosis and portal hypertension. Design A systematic review and meta-analysis. Data sources We searched ...

1 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland 2 Department of Physiology & Health and Physical Activity, Paavo Nurmi Centre, University of ...

Objective Recent clinical studies have shown that anticoagulant therapy might be effective only in specific at-risk subgroups of patients with sepsis and coagulation dysfunction. The definition of ...

1 NIHR CLAHRC for North West London, Chelsea and Westminster Hospital, London, UK 2 Department of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK Setting A wide range ...

Objective To investigate how smoking status is recorded in UK primary care; to evaluate whether appropriate multiple imputation (MI) of smoking status yields results consistent with health surveys.

1 Policy Research Unit in Maternal Health and Care, National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK 2 Mother and Infant Research Unit, College of Medicine, Dentistry and Nursing ...

Introduction Tracheostomy is a common emergency procedure for critically ill patients to secure their airway. The speaking valve is a one-way ventilation valve that is attached to the end of the ...