该家族包括HER1（EGFR）、HER2、HER3和HER4四个成员。HER2在多种癌症中可能过表达或基因扩增，尤其是在乳腺癌、卵巢癌、胃癌、前列腺癌等多个肿瘤中。

a HER2-targeted antibody that disrupts receptor heterodimerization between EGFR/HER2 and HER2/HER3; CP-751871, an IGF1R-targeted antibody; the IGF1R kinase inhibitor NVP-AEW541; and the mammalian ...

EGF receptor (EGFR) and HER2 are two members of the ErbB/HER-family of tyrosine-kinase receptors that are frequently altered in breast cancer and several other malignancies, which inspired the ...

Figure 1. HER3 signaling boosts NSCLC cell growth and survival by forming heterodimers with EGFR, HER2, MET, AXL, or IGF-1R, activating multiple pathways. Image Credit: Sino Biological Inc.

Researchers have hypothesised that inhibiting EGFR and HER3 in tandem could lead to greater ... AZ has already licensed rights to HER2-targeting drug Enhertu (trastuzumab deruxtecan) – which ...