Aminoacyl-tRNA synthetase: An in vivo selection method of aminoacyl-tRNA synthetase variants was developed, and E. coli Arg-tRNA synthetase variants that aminoacylate an amber suppressor tRNA with ...

In order to facilitate these applications, we have: 1) Developed new aminoacyl-tRNA synthetase/tRNA platforms that enable site-specific incorporation of previously inaccessible structural classes of ...

Researchers evolved a ribosome that efficiently decodes quadruplet codons, thus opening up the possibility of genetically incorporating multiple unnatural amino acids into proteins. Imagine being ...

The RNA world hypothesis gains support from the in vitro evolution of a bifunctional ribozyme that can recognize an activated glutaminyl ester and subsequently aminoacylate a tRNA molecule.

Natural and synthetic nonhydrolyzable aminoacyl-adenylate analogs and ... Also shown are the synthetic aspartyl-tRNA synthetase inhibitor DSA and the chemical structure of the unprocessed McC.