These signalling systems operate beyond cell and tissue boundaries, but function as morphogens that are secreted from one cell or tissue type to activate surface receptors, signal transduction ...

Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...

When he added the Wnt-coated beads to dishes in which embryonic stem cells were growing, the scientists could then watch individual cells that were close enough to a bead to receive a Wnt3a signal, ...

They found a significant decrease in a signaling pathway called Wnt/beta-catenin, which helps maintain the health of the blood-brain barrier and protects the brain from damage. With these results, the ...

Dr. Gujral also works to develop better ways to screen potential cancer drugs. Noncanonical Wnt signaling pathway. Dr. Gujral’s lab explores how this pathway contributes to changes in cell state that ...

Surrozen, Inc. (“Surrozen” or the “Company”) (Nasdaq: SRZN), a company pioneering targeted therapeutics that selectively activate the Wnt pathway for tissue repair and regeneration, today announced a ...

Organogenesis requires the proper production of diverse cell types and their positioning/migration. However, the coordination of these processes during development remains poorly understood. The gonad ...