Figure 2: Molecular and cellular changes in skin of wild-type and TNF-α –/– mice during tumor promotion. 'Tumor necrosis factor' might ... TNF-α in the tumor microenvironment is essential ...
Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...
A significant obstacle in treating ovarian cancer is the tumor microenvironment -- the complex ... the researchers discovered that the transcription factor XBP1, which is activated by the ...