The authors first made destabilizing N-terminal truncations in β-lactamase and then used directed evolution to restore activity of the truncated proteins. Because they could not know a priori ...

Sometimes, a ribosome may miss the first AUG start codon and skip ahead to another AUG somewhere in the middle of the gene's ...

This mutation interrupts protein synthesis, generating a truncated, often nonfunctional protein and effectively causing a ...