Contemporary treatment of sepsis follows this patient journey ... including mechanical ventilation, renal replacement therapy and extracorporeal membrane oxygenation 4 (Fig.

In the context of future strategies for the treatment of sepsis, we provide an overview of the various strategies in clinical sepsis trials and review promising research results involving blockade ...

Given the underlying evidence that hyperactivation of the inflammatory system is a feature of sepsis, it is understandable that most therapeutic strategies have targeted pro-inflammatory mediators ...