Similarities to the post-translational modification phosphorylation suggest that AMPylation may be an important regulatory mechanism. Post-translational modifications are key steps in the ...

Post-translational modifications are modifications that occur on a protein, catalysed by enzymes, after its translation by ribosomes is complete. Post-translational modification generally refers ...

These studies revealed structural determinants for recognition of consensus SUMO modification sequences found within SUMO conjugated proteins. Reconstituting SUMO conjugation in vitro revealed ...

A major, but not exclusive focus of our lab is the analysis of histones, their variants, post-translational modifications and proteoforms. Histones are essential regulators of the human genome and ...

Promise Bio, a startup transforming immune-mediated disease treatment with advanced precision medicine solutions, today announced its emergence from stealth with an $8.3 million seed investment. This ...

Despite their therapeutic significance, the mechanism underlying the post-translational modification of a particularly robust class of these peptides remains largely unexplored. Using a ...

Biochemists at the National University of Singapore (NUS) have identified a new subclass of trifunctional enzymes in ...

This guide highlights how advanced analytical tools can uncover post-translational modifications, identify proteoform origins ...

Protein expression and regulation accurately reflect physiological states, which are measured with proteomics. Further, genomics data do not reveal protein levels, their dynamics across time, and post ...

We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like ...