Released glutamate traverses this space by passive diffusion, and because its target glutamate receptors in the postsynaptic neuron are ... states of synapses on a cell-assembly basis.

It seems reasonable that some form of cell–cell signaling must be involved ... However, agrin itself is not necessary for the formation of neuron–neuron synapses. This has led to an intensive ...

An electron micrograph image shows a parallel fiber-Purkinje cell. The presynaptic cell, a parallel fiber, is colored red while the postsynaptic cell, a Purkinje cell, is colored green.

There are two types of removal: Re-uptake – the neurotransmitter is reabsorbed back into the presynaptic neuron and restored inside a vesicle ready to be used again. For example, noradrenaline.

This important study introduces rationally designed, genetically encoded tools for the selective and reversible ablation of excitatory and inhibitory synapses. The evidence is convincing, supported by ...

The brain is an incredibly complex organ, but its billions of neurons have recently been mapped, opening up some fascinating ...

Harvard Medical School neuro-oncologist Annie Hsieh treats patients with gliomas—the most common type of brain cancer, ...

In one set of experiments, Yaeger activated synapses on the pyramidal neurons and measured the effect on the cells' ...

This results in enough neurotransmitter being diffused across the synaptic cleft to trigger the impulse in the postsynaptic neuron. This process is called summation.

This study provides valuable insights into the differential impact of intrinsic and synaptic conductances on circuit robustness, emphasizing intrinsic plasticity as a crucial but often overlooked ...

Scientists at Johns Hopkins Medicine, led by Dr. Shigeki Watanabe, have found that axons aren’t the smooth, cylindrical ...

The signal travels through the cell body and into the neuron ... the transfer of information. When a neuron receives repeated inputs, its synapse undergoes structural changes that make it ...