Pollak, Michael N. Papkovsky, Dmitri B. and Topisirovic, Ivan 2022. Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells.

Did you know that you have a second genome? Small cellular organelles called mitochondria contain their own circular DNA. What happens to your cells when this DNA mutates? Similar to the nuclear ...

In his book, Jan Vijg gives a very comprehensive ... Vijg describes this genome and discusses the significance of DNA damage to mitochondria, which may be an important signaling factor in the ...

known today as mitochondrial DNA (mtDNA). Today mtDNA produces 13 key mitochondrial proteins. As mitochondria age, they change shape and become less active. Eventually they fail and release mtDNA.

Mitochondrial DNA depletion syndrome (MTDPS) is a rare genetic disorder characterized by a marked decrease in mitochondrial DNA (mtDNA).