Achalasia is primarily caused by the degeneration of the myenteric plexus in the esophageal wall, leading to impaired ...

leading to impaired relaxation of the lower esophageal sphincter (LES) and loss of esophageal peristalsis. Although the exact etiology is not fully understood, it is believed to involve autoimmune ...

In the present study, also signs were improved including lower esophageal sphincter (LES) pressure (from 10 ± 1.58 and, 10.3 ± 1.68 mmHg in the pretreated patients to 16.5 ± 0.6, and 14.1 ± 0. ...

Baclofen: acts as a GABA-B receptor antagonist; multiple sites of action: inhibits afferent signals from gastric distention, reduces the threshold of the pattern generator in the brainstem, and ...

The esophagogastric junction or lower esophageal sphincter (the upper aspect of a hiatal hernia). The level of the diaphragmatic impression (the lower aspect of a hiatal hernia). In patients with ...