A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

Regenerating tissues following injury is a demanding task most multicellular organisms master to different levels. In order ...

Thus, neuronal insulin-like signaling appears to be a key regulator of various essential functions in C. elegans, and the metabolic and reproductive defects induced by whole-body deletion of DAF-2 ...

In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor ...

In 2021, a research team discovered the insulin-inhibitory receptor 'Inceptor' and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, even more ...

Leptin and Insulin Resistance Pathway Convergence At the cellular level, leptin signaling intersects with insulin pathways in pancreatic β-cells. When leptin binds to its receptors in these cells ...

In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a ...

suggesting that insulin resistance occurred despite normal insulin signaling pathways. HFD-fed wild-type mice had elevated ...

Diabetes drug development gets an advance in study that shows Inceptor binds excess insulin within the beta cell and directs it towards degradation.

Together with his team, they discovered Inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway. Both Inceptor and the insulin receptor are located on the surface of ...