A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

One possibility is that in an attempt to overcome the inhibition within the metabolic insulin-signaling pathway, hyperinsulinemia may continue to stimulate the mitogenic insulin-signaling pathway ...

Leptin and Insulin Resistance Pathway Convergence At the cellular level, leptin signaling intersects with insulin pathways in ...

When lipid biologist Usha Acharya at the National Cancer Institute (NCI) tinkered with lipid breakdown pathways in Drosophila ...

suggesting that insulin resistance occurred despite normal insulin signaling pathways. HFD-fed wild-type mice had elevated ...

Stress hormones, not impaired insulin signaling, may underlie obesity-related diabetes, according to Rutgers research.

The discovery of a gut-to-brain regulation pathway in flies highlights the potential for certain medications to be further ...

New research suggests that stress hormones, rather than impaired insulin signaling, may primarily drive diabetes in obesity.

The purine/purinergic system has emerged as a fundamental regulator of cellular communication, influencing various physiological processes such as metabolism, energy balance, and signal transduction.

A study from Rutgers Health and other institutions indicates that stress hormones - not impaired cellular insulin signaling - may be the primary ...