A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

Thus, neuronal insulin-like signaling appears to be a key regulator of various essential functions in C. elegans, and the metabolic and reproductive defects induced by whole-body deletion of DAF-2 ...

In vitro assays solidified the lipase’s role as a key mediator of insulin signaling. The researchers found that Vaha breaks ...

Additionally, chronic endoplasmic reticulum (ER) stress and inflammation from high-fat diets further disrupt leptin signaling ...

The discovery of a gut-to-brain regulation pathway in flies highlights the potential for certain medications to be further ...

"We know that reducing insulin, and reducing IGF signaling, slows aging and extends lifespan in flies," Tatar said. Tatar ...