LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene sequences.

How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell development in chickens, the investigators started with whole chromatin from ...

Caltech researchers have developed a new method to map the positions of hundreds of DNA-associated proteins within cell ...

DNA methylation and histone modification influence each other during development. Histone methylation can help to direct DNA methylation patterns, and DNA methylation seems to serve as a template ...

Small chemical modifications can be added to histones, which allow proteins to access the tightly bound DNA from their histone bookcases to turn "on" and "off" genes in the organism. With ready ...

Liver diseases represent a significant global health challenge, encompassing a spectrum of conditions such as hepatitis, fatty liver disease, cirrhosis, and hepatocellular carcinoma. Recent ...

Welcome back to Genomics Week in Brief – your number one stop for all the latest and greatest genomics news (and more)!

At the core of vascular pathologies, a critical transformation occurs as cells undergo epigenetic-induced phenotypic transitions, adopting roles that promote disease. These changes are mediated by a ...

Based on this, Peng and Qin further comprehensively summarized the epigenetic regulation mechanism of oxidative stress on tumor metastasis, from DNA methylation, histone modification, ncRNAs and ...

Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and ...