Theoretically, the RAS may be interrupted at any of several points in the stepwise, enzyme-catalyzed synthesis of angiotensin II, and the action of the angiotensin II molecule, once synthesized ...

Angiotensin II has complex effects on the heart and kidneys ... Candesartan cilexetil is a prodrug. The initial form of the drug (clinically active or requiring metabolic activation) is unrelated ...

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Angiotensin I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Angiotensin II David W. Cushman In 1967, John Vane, a consultant at The Squibb Institute for Medical Research ...

Two classes of antihypertensives target angiotensin II, either through preventing its formation by inhibiting ACE or by preventing angiotensin II from binding to receptors on blood vessels.