Theoretically, the RAS may be interrupted at any of several points in the stepwise, enzyme-catalyzed synthesis of angiotensin II, and the action of the angiotensin II molecule, once synthesized ...

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Angiotensin I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Angiotensin II David W. Cushman In 1967, John Vane, a consultant at The Squibb Institute for Medical Research ...

Two classes of antihypertensives target angiotensin II, either through preventing its formation by inhibiting ACE or by preventing angiotensin II from binding to receptors on blood vessels.

Numerous clinical studies have established that angiotensin II receptor blockers are effective as antihypertensive therapy and are well tolerated. Studies demonstrate that adding an angiotensin II ...