maintained the characteristics of an embryonic stem cell, while the distant (or distal) cell turned on genes indicating it had begun to differentiate into the more specialized cell known as an ...

Embryonic stem cells are pluripotent cells isolated from ... and uncover a collaboration of Smad2/3 with Dnmt3b in epiblast formation.

Chemicals were then used to coax these stem cells into becoming four types of cell found in the earliest stages of the human embryo: epiblast cells, which become the embryo proper (or foetus ...

To this end, they developed a novel embryo-like model system consisting of a layer of epiblast and a layer of VE cells—a cup without a lid. They achieved this with the targeted and controlled ...