Mutant BCL6 will abnormally situate near genes that trigger apoptosis ... a Professor at Stanford. This method aims to turn on a pathway that is normally off, instead of inhibiting something that ...

Sarott et al. set out to repurpose these CDK inhibitors as chemical inducers of proximity (CIPs) that activate genes repressed by the DNA-binding transcription factor BCL6. This oncoprotein ...

Image: the BCL6 BTB domain dimer (in grey/green) and compound hits in pink, superimposed on each other in the main compound binding site. Dr Rob van Montfort lab / ICR Scientists have revealed details ...