Glioblastoma multiforme is an extreme example. Antiangiogenic therapy has been combined with radiotherapy with mixed results: additive or synergistic tumor growth delay, or reduced response.

However, lack of response to antiangiogenic drugs and adverse drug reactions leading to treatment suspension are critical clinical problems that need to be solved. Because antiangiogenic drugs act ...

which indicate that the antiangiogenic effects of bevacizumab might persist despite the development of resistance to first-line chemotherapy. For decades, cancer therapy has been rooted in the ...

Figure 1: α v β 3 as a mediator of antiangiogenic regulators. Figure 2: Trans-dominant inhibition of proangiogenic integrins. In presenting these models for negative regulation by α v integrins ...

Angiopoietin-2 (ANGPT2) is a ligand of the receptor tyrosine kinase TIE2 (TEK). In conjunction with vascular endothelial growth factor (VEGF), ANGPT2-TIE2 signaling induces vascular sprouting.