Afrin is an over-the-counter (OTC) decongestant nasal spray that works by attaching to receptors in the blood vessels in the nose and sinuses, causing them to narrow (constrict). Afrin (a brand ...

Avoid spraying the medication into your eyes or onto the middle of the inside of your nose (nasal septum). Rinse the spray tip with hot water or wipe with a clean tissue after each use.